The recent epidemics and pandemics, in particular COVID-19, have made it unmistakably clear that human, animal, plant and environmental health cannot be dealt with separately, but need to be addressed in a ‘One Health’ approach. Their interdependencies need to be better acknowledged and require work at the interfaces in a multisectoral, transdisciplinary and an integrated approach. Mainstreaming ‘One Health’ means that we can better prevent, predict, prepare for, detect, and respond to global health threats at both global and EU level