One Health (OH) is a collaborative multisectoral and transdisciplinary approach that aims to sustainably balance and optimize the health of humans, domestic and wild animals, plants, and the wider environment, which are closely linked and interdependent [1]. In Africa, OH faces a number of challenges in its implementation, some of which revolve around capacity both at the technical and societal level, leading to unsustainable and scattered One Health efforts. Other key issues such as lack of cross-departmental collaboration; inability to adapt health solutions to the national context and effectively cascade solutions down to final beneficiaries; inadequate research infrastructure, limited funding, as well as weak integration of efforts, are significantly contributing toward ineffective implementation of the OH approach.