Zambia’s unique location as a land-linked country also places it at a higher risk of being a hotspot for emerging and re-emerging infectious disease threats in the region arising from international travel. Over the last decade, the surrounding regions have experienced animal-originating outbreaks of Ebola, Marburg haemorrhagic fever, Rift valley fever, Crimean Congo haemorrhagic fever and yellow fever. These outbreaks have resulted in significant illness, death and social disruption in the affected communities and beyond. In addition to the dangers of well-known zoonotic diseases like Rabies and Anthrax, more insidious threats lurk at the human-animal-ecosystem interface, with the growing resistance of microbes to antibiotics.